IGF-1 LR3

IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a synthetic analog of naturally occurring IGF-1, studied in research settings for its role in cellular growth signaling, metabolic regulation, and protein synthesis pathways. In simple terms, researchers use IGF-1 LR3 to better understand how growth factor signaling influences cell communication, nutrient uptake, and tissue development processes in controlled laboratory models.

From a technical standpoint, IGF-1 LR3 is a modified version of human IGF-1 with an extended N-terminal sequence (Arg3-IGF-1) and amino acid substitutions that significantly reduce binding affinity to IGF-binding proteins (IGFBPs). This modification increases its biological half-life and enhances receptor availability in research models. IGF-1 LR3 exerts its effects primarily through the IGF-1 receptor (IGF-1R), activating downstream signaling pathways such as PI3K/Akt and MAPK/ERK, which are involved in cellular growth, differentiation, and metabolic regulation.

In preclinical research, IGF-1 LR3 is commonly studied in relation to muscle tissue signaling, cellular proliferation, glucose uptake mechanisms, and anabolic pathway activity. It is frequently used as a model compound in studies examining growth factor biology, endocrine signaling interactions, and nutrient-dependent cellular responses.

IGF-1 LR3 is intended strictly for laboratory research purposes only and is not approved for human consumption, medical use, or diagnostic applications.

Key Research Areas

• IGF-1 receptor (IGF-1R) signaling pathways
• Cellular growth, proliferation, and differentiation models
• PI3K/Akt and MAPK/ERK pathway activation
• Protein synthesis and anabolic signaling research
• Glucose uptake and metabolic regulation studies

Chemical Information

• Compound Name: IGF-1 LR3 (Long R3 IGF-1)
• Type: Synthetic growth factor analog
• Modification: Reduced IGF-binding protein affinity (Arg3 substitution)
• Receptor Target: IGF-1 receptor (IGF-1R)
• Research Focus: Cellular growth and metabolic signaling pathways

Important Notice

This compound is sold strictly for laboratory research purposes only. It is not intended for human consumption, medical treatment, or diagnostic use. Proper handling and regulatory compliance are required by the purchaser.